Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC6678704 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Wang Dennis D Pham Nhu-An NA Freeman Timothy M TM Raghavan Vibha V Navab Roya R Chang Jonathan J Zhu Chang-Qi CQ Ly Dalam D Tong Jiefei J Wouters Bradly G BG Pintilie Melania M Moran Michael F MF Liu Geoffrey G Shepherd Frances A FA Tsao Ming-Sound MS
Cancers 20190719 7
The burden of somatic mutations and neoantigens has been associated with improved survival in cancer treated with immunotherapies, especially non-small cell lung cancer (NSCLC). However, there is uncertainty about their effect on outcome in early-stage untreated cases. We posited that the burden of mutations in a specific set of genes may also contribute to the prognosis of early NSCLC patients. From a small cohort of 36 NSCLC cases, we were able to identify somatic mutations and copy number alt ...[more]