Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez-Pascual A
PROVIDER: S-EPMC6678715 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Jimenez-Pascual Ana A Siebzehnrubl Florian A FA
Cells 20190713 7
Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma. Somatic mutations of fibroblast growth factor receptors (<i>FGFRs</i>) are rare in these cancers, but many studies have documented that signaling through FGFRs impacts glioblastoma progression and patient survival. Small-molecul ...[more]