Ontology highlight
ABSTRACT:
SUBMITTER: Mas L
PROVIDER: S-EPMC6679157 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Mas Leo L Bachet Jean-Baptiste JB Taly Valerie V Bouché Olivier O Taieb Julien J Cohen Romain R Cohen Romain R Meurisse Aurelia A Normand Corinne C Gornet Jean-Marc JM Artru Pascal P Louafi Samy S Thirot-Bidault Anne A Baumgaertner Isabelle I Coriat Romain R Tougeron David D Lecomte Thierry T Mary Florence F Aparicio Thomas T Marthey Lysiane L Blons Helene H Vernerey Dewi D Laurent-Puig Pierre P
Cancers 20190717 7
In patients with metastatic colorectal cancer (mCRC), <i>RAS</i> and <i>BRAF</i> mutations are currently determined by tumor sample analysis. Here, we report <i>BRAF</i> mutation status analysis in paired tumor tissue and plasma samples of mCRC patients included in the AGEO RASANC prospective cohort study. Four hundred and twenty-five patients were enrolled. Plasma samples were analyzed by next-generation sequencing (NGS). When no mutation was identified, we used two methylated specific biomarke ...[more]