Ontology highlight
ABSTRACT:
SUBMITTER: Kim EA
PROVIDER: S-EPMC6679220 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kim Eun-Ae EA Jang Ji-Hoon JH Sung Eon-Gi EG Song In-Hwan IH Kim Joo-Young JY Lee Tae-Jin TJ
International journal of molecular sciences 20190719 14
MicroRNAs (miRNAs) can be used to target a variety of human malignancies by targeting their oncogenes or tumor suppressor genes. Recent evidence has shown that miRNA-1208 (miR-1208) was rarely expressed in a variety of cancer cells, suggesting the possibility that miR-1208 functions as a tumor suppressor gene. Herein, ectopic expression of miR-1208 induced the accumulation of sub-G1 populations and the cleavage of procaspase-3 and PARP, which could be prevented by pre-treatment with the pan-casp ...[more]