Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Z
PROVIDER: S-EPMC6679753 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhu Zhihui Z Chen Jianzhong J Wang Guanghu G Elsherbini Ahmed A Zhong Liansheng L Jiang Xue X Qin Haiyan H Tripathi Priyanka P Zhi Wenbo W Spassieva Stefka D SD Morris Andrew J AJ Bieberich Erhard E
Biochimica et biophysica acta. Molecular and cell biology of lipids 20190605 10
The sphingolipid ceramide regulates beta-oxidation of medium and long chain fatty acids in mitochondria. It is not known whether it also regulates oxidation of very long chain fatty acids (VLCFAs) in peroxisomes. Using affinity chromatography, co-immunoprecipitation, and proximity ligation assays we discovered that ceramide interacts with Hsd17b4, an enzyme critical for peroxisomal VLCFA oxidation and docosahexaenoic acid (DHA) generation. Immunocytochemistry showed that Hsd17b4 is distributed t ...[more]