Ontology highlight
ABSTRACT:
SUBMITTER: Chera BS
PROVIDER: S-EPMC6679766 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Chera Bhishamjit S BS Kumar Sunil S Beaty Brian T BT Marron David D Jefferys Stuart S Green Rebecca R Goldman Emily C EC Amdur Robert R Sheets Nathan N Dagan Roi R Hayes D Neil DN Weiss Jared J Grilley-Olson Juneko E JE Zanation Adam A Hackman Trevor T Blumberg Jeffrey M JM Patel Samip S Weissler Mark M Tan Xianming M XM Parker Joel S JS Mendenhall William W Gupta Gaorav P GP
Clinical cancer research : an official journal of the American Association for Cancer Research 20190514 15
<h4>Purpose</h4>To identify a profile of circulating tumor human papilloma virus (HPV) DNA (ctHPVDNA) clearance kinetics that is associated with disease control after chemoradiotherapy (CRT) for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).<h4>Experimental design</h4>A multi-institutional prospective biomarker trial was conducted in 103 patients with (i) p16-positive OPSCC, (ii) M0 disease, and (iii) receipt of definitive CRT. Blood specimens were collected at baseline, weekly du ...[more]