Ontology highlight
ABSTRACT:
SUBMITTER: Schnell G
PROVIDER: S-EPMC6680211 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Schnell Gretja G Tripathi Rakesh R Krishnan Preethi P Beyer Jill J Reisch Thomas T Irvin Michelle M Dekhtyar Tatyana T Setze Carolyn C Rodrigues Lino L Alves Katia K Burroughs Margaret M Redman Rebecca R Chayama Kazuaki K Kumada Hiromitsu H Collins Christine C Pilot-Matias Tami T
Journal of medical virology 20170922 1
Treatment of HCV genotype (GT) 2-infected Japanese patients with paritaprevir (NS3/4A inhibitor boosted with ritonavir) and ombitasvir (NS5A inhibitor) without ribavirin for 12 weeks in the phase 2 study M12-536, and with ribavirin for 16 weeks in phase 3 study GIFT II resulted in SVR rates of 72.2% to 91.5%. Overall, 11 out of 125 patients with GT2a and 37 out of 79 patients with GT2b infection experienced virologic failure. The prevalence of baseline polymorphisms in NS3 and NS5A and their the ...[more]