Ontology highlight
ABSTRACT:
SUBMITTER: Musolino SF
PROVIDER: S-EPMC6680239 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Chemistry (Weinheim an der Bergstrasse, Germany) 20161130 52
The non-enzymatic acylative kinetic resolution of challenging aryl-alkenyl (sp<sup>2</sup> vs. sp<sup>2</sup> ) substituted secondary alcohols is described, with effective enantiodiscrimination achieved using the isothiourea organocatalyst HyperBTM (1 mol %) and isobutyric anhydride. The kinetic resolution of a wide range of aryl-alkenyl substituted alcohols has been evaluated, with either electron-rich or naphthyl aryl substituents in combination with an unsubstituted vinyl substituent providin ...[more]