Ontology highlight
ABSTRACT:
SUBMITTER: Abdallah EA
PROVIDER: S-EPMC6680263 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Abdallah Emne Ali EA Fanelli Marcello Ferretti MF Buim Marcilei Eliza Cavicchioli ME Machado Netto Marcelo Calil MC Gasparini Junior José Luiz JL Souza E Silva Virgílio V Dettino Aldo Lourenço Abbade AL Mingues Natalia Breve NB Romero Juliana Valim JV Ocea Luciana Menezes Mendonça LM Rocha Bruna Maria Malagoli BM Alves Vanessa Silva VS Araújo Daniel Vilarim DV Chinen Ludmilla Thomé Domingos LT
International journal of cancer 20150311 6
Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemotherapy. The blood was filtered on Isolation by Size of Epithelial Tumor Cells (ISET), and the analysis of TYMS expression in CTCs was made by immunocytochemistry. Additionally, we ...[more]