Dataset Information

Competition in Coordination Assemblies: 1D-Coordination Polymer or 2D-Nets Based on Co(NCS)₂ and 4'-(4-methoxyphenyl)-3,2':6',3″-terpyridine.

ABSTRACT: The synthesis and characterization of 4'-(4-methoxyphenyl)-3,2':6',3″-terpyridine (2) (IUPAC PIN 2⁴-(4-methoxyphenyl)-1²,2²:2⁶,3²-terpyridine) are described, and its coordination behaviour with cobalt(II) thiocyanate has been investigated. In a series of experiments, crystals were grown at room temperature by layering a MeOH solution of Co(NCS)₂ over a CHCl₃ solution of 2 using 1:1, 1:2 or 2:1 molar ratios of metal salt-to-ligand. Crystals harvested within 2-3 weeks proved to be the 1D-coordination polymer [Co(2)(NCS)₂(MeOH)₂]_n and powder X-ray diffraction (PXRD) confirmed that the crystals selected for single-crystal X-ray diffraction were representative of the bulk samples. Longer crystallization times with a Co(NCS)₂ to 2 molar ratio of 1:1 yielded crystals of [Co(2)(NCS)₂(MeOH)₂]_n (1D-chain) and the pseudopolymorphs [{Co(2)₂(NCS)₂}·3MeOH]_n and [{Co(2)₂(NCS)₂}·2.2CHCl₃]_n ((4,4)-nets), each type of crystal originating from a different zone in the crystallization tube. PXRD for this last experiment confirmed that the dominant product in the bulk sample was the 1D-coordination polymer.

SUBMITTER: Rocco D

PROVIDER: S-EPMC6680941 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:Understanding how cells migrate in fibrous environments is important in wound healing, immune function, and cancer progression. A key question is how fiber orientation and network geometry influence cell movement. Here we describe a quantitative, modeling-based approach toward identifying the mechanisms by which cells migrate in fibrous geometries having well controlled orientation. Specifically, U251 glioblastoma cells were seeded onto non-electrospinning Spinneret based tunable engineering parameters fiber substrates that consist of networks of suspended 400 nm diameter nanofibers. Cells were classified based on the local fiber geometry and cell migration dynamics observed by light microscopy. Cells were found in three distinct geometries: adhering two a single fiber, adhering to two parallel fibers, and adhering to a network of orthogonal fibers. Cells adhering to a single fiber or two parallel fibers can only move in one dimension along the fiber axis, whereas cells on a network of orthogonal fibers can move in two dimensions. We found that cells move faster and more persistently in 1D geometries than in 2D, with cell migration being faster on parallel fibers than on single fibers. To explain these behaviors mechanistically, we simulated cell migration in the three different geometries using a motor-clutch based model for cell traction forces. Using nearly identical parameter sets for each of the three cases, we found that the simulated cells naturally replicated the reduced migration in 2D relative to 1D geometries. In addition, the modestly faster 1D migration on parallel fibers relative to single fibers was captured using a correspondingly modest increase in the number of clutches to reflect increased surface area of adhesion on parallel fibers. Overall, the integrated modeling and experimental analysis shows that cell migration in response to varying fibrous geometries can be explained by a simple mechanical readout of geometry via a motor-clutch mechanism.

Dataset Information

Competition in Coordination Assemblies: 1D-Coordination Polymer or 2D-Nets Based on Co(NCS)₂ and 4'-(4-methoxyphenyl)-3,2':6',3″-terpyridine.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Competition in Coordination Assemblies: 1D-Coordination Polymer or 2D-Nets Based on Co(NCS)2 and 4'-(4-methoxyphenyl)-3,2':6',3″-terpyridine.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Competition in Coordination Assemblies: 1D-Coordination Polymer or 2D-Nets Based on Co(NCS)₂ and 4'-(4-methoxyphenyl)-3,2':6',3″-terpyridine.