IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.
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ABSTRACT:
SUBMITTER: Hotter D
PROVIDER: S-EPMC6681451 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.
Hotter Dominik D Bosso Matteo M Jønsson Kasper L KL Krapp Christian C Stürzel Christina M CM Das Atze A Littwitz-Salomon Elisabeth E Berkhout Ben B Russ Alina A Wittmann Sabine S Gramberg Thomas T Zheng Yue Y Martins Laura J LJ Planelles Vicente V Jakobsen Martin R MR Hahn Beatrice H BH Dittmer Ulf U Sauter Daniel D Kirchhoff Frank F
Cell host & microbe 20190604 6
The interferon γ-inducible protein 16 (IFI16) is known as immune sensor of retroviral DNA intermediates. We show that IFI16 restricts HIV-1 independently of immune sensing by binding and inhibiting the host transcription factor Sp1 that drives viral gene expression. This antiretroviral activity and ability to bind Sp1 require the N-terminal pyrin domain and nuclear localization of IFI16, but not the HIN domains involved in DNA binding. Highly prevalent clade C HIV-1 strains are more resistant to ...[more]
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2010-06-06 | E-GEOD-1441 | biostudies-arrayexpress
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