Dataset Information

Generation of PET Attenuation Map for Whole-Body Time-of-Flight 18F-FDG PET/MRI Using a Deep Neural Network Trained with Simultaneously Reconstructed Activity and Attenuation Maps.

ABSTRACT: We propose a new deep learning-based approach to provide more accurate whole-body PET/MRI attenuation correction than is possible with the Dixon-based 4-segment method. We use activity and attenuation maps estimated using the maximum-likelihood reconstruction of activity and attenuation (MLAA) algorithm as inputs to a convolutional neural network (CNN) to learn a CT-derived attenuation map. Methods: The whole-body 18F-FDG PET/CT scan data of 100 cancer patients (38 men and 62 women; age, 57.3 ± 14.1 y) were retrospectively used for training and testing the CNN. A modified U-net was trained to predict a CT-derived ?-map (?-CT) from the MLAA-generated activity distribution (?-MLAA) and ?-map (?-MLAA). We used 1.3 million patches derived from 60 patients' data for training the CNN, data of 20 others were used as a validation set to prevent overfitting, and the data of the other 20 were used as a test set for the CNN performance analysis. The attenuation maps generated using the proposed method (?-CNN), ?-MLAA, and 4-segment method (?-segment) were compared with the ?-CT, a ground truth. We also compared the voxelwise correlation between the activity images reconstructed using ordered-subset expectation maximization with the ?-maps, and the SUVs of primary and metastatic bone lesions obtained by drawing regions of interest on the activity images. Results: The CNN generates less noisy attenuation maps and achieves better bone identification than MLAA. The average Dice similarity coefficient for bone regions between ?-CNN and ?-CT was 0.77, which was significantly higher than that between ?-MLAA and ?-CT (0.36). Also, the CNN result showed the best pixel-by-pixel correlation with the CT-based results and remarkably reduced differences in activity maps in comparison to CT-based attenuation correction. Conclusion: The proposed deep neural network produced a more reliable attenuation map for 511-keV photons than the 4-segment method currently used in whole-body PET/MRI studies.

SUBMITTER: Hwang D

PROVIDER: S-EPMC6681691 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Generation of PET Attenuation Map for Whole-Body Time-of-Flight 18F-FDG PET/MRI Using a Deep Neural Network Trained with Simultaneously Reconstructed Activity and Attenuation Maps.

Hwang Donghwi D Kang Seung Kwan SK Kim Kyeong Yun KY Seo Seongho S Paeng Jin Chul JC Lee Dong Soo DS Lee Jae Sung JS

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20190125 8

We propose a new deep learning-based approach to provide more accurate whole-body PET/MRI attenuation correction than is possible with the Dixon-based 4-segment method. We use activity and attenuation maps estimated using the maximum-likelihood reconstruction of activity and attenuation (MLAA) algorithm as inputs to a convolutional neural network (CNN) to learn a CT-derived attenuation map. Methods: The whole-body 18F-FDG PET/CT scan data of 100 cancer patients (38 men and 62 w ...[more]

PMID: 30683763

Similar Datasets

Project description:PURPOSE:The aim of this study was to evaluate and quantify the effect of improved attenuation correction (AC) including bone segmentation and truncation correction on 18F-Fluordesoxyglucose cardiac positron emission tomography/magnetic resonance (PET/MR) imaging. METHODS:PET data of 32 cardiac PET/MR datasets were reconstructed with three different AC-maps (1. Dixon-VIBE only, 2. HUGE truncation correction and bone segmentation, 3. MLAA). The Dixon-VIBE AC-maps served as reference of reconstructed PET data. 17-segment short-axis polar plots of the left ventricle were analyzed regarding the impact of each of the three AC methods on PET quantification in cardiac PET/MR imaging. Non-AC PET images were segmented to specify the amount of truncation in the Dixon-VIBE AC-map serving as a reference. All AC-maps were evaluated for artifacts. RESULTS:Using HUGE + bone AC results in a homogeneous gain of ca. 6% and for MLAA 8% of PET signal distribution across the myocardium of the left ventricle over all patients compared to Dixon-VIBE AC only. Maximal relative differences up to 18% were observed in segment 17 (apex). The body volume truncation of -12.7 ± 7.1% compared to the segmented non-AC PET images using the Dixon-VIBE AC method was reduced to -1.9 ± 3.9% using HUGE and 7.8 ± 8.3% using MLAA. In each patient, a systematic overestimation in AC-map volume was observed when applying MLAA. Quantitative impact of artifacts showed regional differences up to 6% within single segments of the myocardium. CONCLUSIONS:Improved AC including bone segmentation and truncation correction in cardiac PET/MR imaging is important to ensure best possible diagnostic quality and PET quantification. The results exhibited an overestimation of AC-map volume using MLAA, while HUGE resulted in a more realistic body contouring. Incorporation of bone segmentation into the Dixon-VIBE AC-map resulted in homogeneous gain in PET signal distribution across the myocardium. The majority of observed AC-map artifacts did not significantly affect the quantitative assessment of the myocardium.

Project description:BACKGROUND:Attenuation correction (AC) of PET data is usually performed using a second imaging for the generation of attenuation maps. In certain situations however-when CT- or MR-derived attenuation maps are corrupted or CT acquisition solely for the purpose of AC shall be avoided-it would be of value to have the possibility of obtaining attenuation maps only based on PET information. The purpose of this study was to thus develop, implement, and evaluate a deep learning-based method for whole body [18F]FDG-PET AC which is independent of other imaging modalities for acquiring the attenuation map. METHODS:The proposed method is investigated on whole body [18F]FDG-PET data using a Generative Adversarial Networks (GAN) deep learning framework. It is trained to generate pseudo CT images (CTGAN) based on paired training data of non-attenuation corrected PET data (PETNAC) and corresponding CT data. Generated pseudo CTs are then used for subsequent PET AC. One hundred data sets of whole body PETNAC and corresponding CT were used for training. Twenty-five PET/CT examinations were used as test data sets (not included in training). On these test data sets, AC of PET was performed using the acquired CT as well as CTGAN resulting in the corresponding PET data sets PETAC and PETGAN. CTGAN and PETGAN were evaluated qualitatively by visual inspection and by visual analysis of color-coded difference maps. Quantitative analysis was performed by comparison of organ and lesion SUVs between PETAC and PETGAN. RESULTS:Qualitative analysis revealed no major SUV deviations on PETGAN for most anatomic regions; visually detectable deviations were mainly observed along the diaphragm and the lung border. Quantitative analysis revealed mean percent deviations of SUVs on PETGAN of - 0.8 ± 8.6% over all organs (range [- 30.7%, + 27.1%]). Mean lesion SUVs showed a mean deviation of 0.9 ± 9.2% (range [- 19.6%, + 29.2%]). CONCLUSION:Independent AC of whole body [18F]FDG-PET is feasible using the proposed deep learning approach yielding satisfactory PET quantification accuracy. Further clinical validation is necessary prior to implementation in clinical routine applications.

Project description:Dedicated brain positron emission tomography (PET) devices can provide higher-resolution images with much lower doses compared to conventional whole-body PET systems, which is important to support PET neuroimaging and particularly useful for the diagnosis of neurodegenerative diseases. However, when a dedicated brain PET scanner does not come with a combined CT or transmission source, there is no direct solution for accurate attenuation and scatter correction, both of which are critical for quantitative PET. To address this problem, we propose joint attenuation and scatter correction (ASC) in image space for non-corrected PET (PETNC) using deep convolutional neural networks (DCNNs). This approach is a one-step process, distinct from conventional methods that rely on generating attenuation maps first that are then applied to iterative scatter simulation in sinogram space. For training and validation, time-of-flight PET/MR scans and additional helical CTs were performed for 35 subjects (25/10 split for training and test dataset). A DCNN model was proposed and trained to convert PETNC to DCNN-based ASC PET (PETDCNN) directly in image space. For quantitative evaluation, uptake differences between PETDCNN and reference CT-based ASC PET (PETCT-ASC) were computed for 116 automated anatomical labels (AALs) across 10 test subjects (1160 regions in total). MR-based ASC PET (PETMR-ASC), a current clinical protocol in PET/MR imaging, was another reference for comparison. Statistical significance was assessed using a paired t test. The performance of PETDCNN was comparable to that of PETMR-ASC, in comparison to reference PETCT-ASC. The mean SUV differences (mean ± SD) from PETCT-ASC were 4.0% ± 15.4% (P < 0.001) and -4.2% ± 4.3% (P < 0.001) for PETDCNN and PETMR-ASC, respectively. The overall larger variation of PETDCNN (15.4%) was prone to the subject with the highest mean difference (48.5% ± 10.4%). The mean difference of PETDCNN excluding the subject was substantially improved to -0.8% ± 5.2% (P < 0.001), which was lower than that of PETMR-ASC (-5.07% ± 3.60%, P < 0.001). In conclusion, we demonstrated the feasibility of directly producing PET images corrected for attenuation and scatter using a DCNN (PETDCNN) from PETNC in image space without requiring conventional attenuation map generation and time-consuming scatter correction. Additionally, our DCNN-based method provides a possible alternative to MR-ASC for simultaneous PET/MRI.

Project description:BACKGROUND:Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alterations in 5-HT1A receptor binding following stress exposure. Considering the possible role of 5-HT1A receptors in stress coping mechanisms, respective imaging approaches are of particular interest. MATERIAL AND METHODS:For twelve consecutive days, Sprague Dawley rats were exposed to daily transport with a 1?h stay in a laboratory or daily transport plus 1?h restraint in a narrow tube. Following, animals were subjected to ?PET imaging with 2'-methoxyphenyl-(N-2'-pyridinyl)-p-[18F]fluoro-benzamidoethylpiperazine ([18F]MPPF) and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). Behavioral and biochemical parameters were analyzed to obtain additional information. RESULTS:In rats with repeated transport, hippocampal [18F]MPPF binding exceeded that in the naive group, while no difference in [18F]FDG uptake was detected between the groups. A transient decline in body weight was observed in rats with transport or combined transport and restraint. Thereby, body weight development correlated with [18F]MPPF binding. CONCLUSIONS:Mild-to-moderate stress associated with daily transport and exposure to a laboratory environment can trigger significant alterations in hippocampal binding of the 5-HT1A receptor ligand [18F]MPPF. This finding indicates that utmost care is necessary to control and report transport and associated handling procedures for animals used in ?PET studies analyzing the serotonergic system in order to enhance the robustness of conclusions and allow replicability of findings. In view of earlier studies indicating that an increase in hippocampal 5-HT1A receptor expression may be associated with a resilience to stress, it would be of interest to further evaluate 5-HT1A receptor imaging approaches as a candidate biomarker for the vulnerability to stress.

Dataset Information

Generation of PET Attenuation Map for Whole-Body Time-of-Flight 18F-FDG PET/MRI Using a Deep Neural Network Trained with Simultaneously Reconstructed Activity and Attenuation Maps.

Publications

Generation of PET Attenuation Map for Whole-Body Time-of-Flight <sup>18</sup>F-FDG PET/MRI Using a Deep Neural Network Trained with Simultaneously Reconstructed Activity and Attenuation Maps.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure