Macromolecular Probe Based on a NiII/TbIII Coordination Polymer for Sensitive Recognition of Human Serum Albumin (HSA) and MnO4.

ABSTRACT: Reported here are the design and fluorescence characters of a NiII/TbIII polymer, [Tb2Ni3(HCAM)6(H2O)12] n (1) (H3CAM = chelidamic acid). Under physiological conditions, the binding of biocompatible water soluble 1 to human serum albumin (HSA) was studied by spectroscopy techniques, which revealed that 1 could inherent the fluorescent light of HSA in a static quencher course and change the HSA second-level structure. The marked enhancement in 1 and its fluorescence intensity provide conclusive evidence that 1 can play the role of a "turn-on" sensor for recognition and detection of HSA in other biological interferents with a K sv value of 7.68 × 104 M-1 and a detection limit of 0.14 ?M. Luminescence experiments show that 1 has high selectivity and sensitivity to MnO4 - in other anions. Its quenching efficiency (K sv) is 5.54 × 103 M-1, and the detection limit is 0.29 ?M.

SUBMITTER: Qian J 

PROVIDER: S-EPMC6682116 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature