Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations.
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ABSTRACT:
SUBMITTER: Miklja Z
PROVIDER: S-EPMC6682212 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations.
Miklja Zachary Z Pasternak Amy A Stallard Stefanie S Nicolaides Theodore T Kline-Nunnally Cassie C Cole Bonnie B Beroukhim Rameen R Bandopadhayay Pratiti P Chi Susan S Ramkissoon Shakti H SH Mullan Brendan B Bruzek Amy K AK Gauthier Angela A Garcia Taylor T Atchison Christie C Marini Bernard B Fouladi Maryam M Parsons D William DW Leary Sarah S Mueller Sabine S Ligon Keith L KL Koschmann Carl C
Neuro-oncology 20190801 8
As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of inco ...[more]
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