Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold.

ABSTRACT: Tuberculosis (TB) remains a significant global health problem for which new therapeutic options are sorely needed. The ability of the causative agent, Mycobacterium tuberculosis, to reside within host macrophages and form biofilm-like communities contributes to the persistent and drug-tolerant nature of the disease. Compounds that can prevent or reverse the biofilm-like phenotype have the potential to serve alongside TB antibiotics to overcome this tolerance, and decrease treatment duration. Using Mycobacterium smegmatis as a surrogate organism, we report the identification of two new 2-aminoimidazole compounds that inhibit and disperse mycobacterial biofilms, work synergistically with isoniazid and rifampicin to eradicate preformed M. smegmatis biofilms in vitro, are nontoxic toward Galle

SUBMITTER: Nguyen TV 

PROVIDER: S-EPMC6682311 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature