The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M.?tuberculosis to ?-Lactam Antibiotics in a Pattern Distinct from ?-Lactamase Inhibitors.
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ABSTRACT:
SUBMITTER: Nguyen TV
PROVIDER: S-EPMC6682314 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.
Nguyen T Vu TV Blackledge Meghan S MS Lindsey Erick A EA Minrovic Bradley M BM Ackart David F DF Jeon Albert B AB Obregón-Henao Andrés A Melander Roberta J RJ Basaraba Randall J RJ Melander Christian C
Angewandte Chemie (International ed. in English) 20170301 14
A library of 2-aminobenzimidazole derivatives was screened for the ability to suppress β-lactam resistance in Mycobacterium smegmatis. Several non-bactericidal compounds were identified that reversed intrinsic resistance to β-lactam antibiotics in a manner distinct from β-lactamase inhibitors. Activity also translates to M. tuberculosis, with a lead compound from this study potently suppressing carbenicillin resistance in multiple M. tuberculosis strains (including multidrug-resistant strains). ...[more]
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