Ontology highlight
ABSTRACT:
SUBMITTER: Nelson N
PROVIDER: S-EPMC6682348 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Oncoimmunology 20190426 8
<i>In vitro</i> assays that evaluate CD8<sup>+</sup> T cell-mediated cytotoxicity are important to aid in the development of novel therapeutic approaches to enhance anti-tumor immune responses. Here, we describe a novel cytotoxicity co-culture assay that circumvents the problem of highly variable allogeneic responses and obviates the constraints of HLA-restriction between effector and target cells. We show that this assay can be easily applied to a panel of tumor cell lines to provide additional ...[more]