Dataset Information

Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

ABSTRACT:

Objectives

To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with ^99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection.

Methods

Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using ^99mTc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake function was calculated for both modalities: mebrofenin uptake rate (MUR) and Ki respectively. The FRL was delineated with both SPECT-CT and MRI to calculate the functional share. Blood samples were taken to assess biochemical liver parameters.

Results

A total of 20 patients were included. The HBS-derived MUR and the DHCE-MRI-derived mean Ki correlated strongly for both total and FRL function (Pearson r?=?0.70, p?=?0.001 and r?=?0.89, p?ConclusionsAssessment of liver function with DHCE-MRI is comparable with that of ^99mTc-mebrofenin HBS and has the potential to be combined with diagnostic MRI imaging. This can therefore provide a one-stop-shop modality for the preoperative assessment of patients undergoing liver surgery.

Key points

• Quantitative assessment of liver function using hepatobiliary scintigraphy is performed in the preoperative assessment of patients undergoing liver surgery in order to prevent posthepatectomy liver failure. • Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) is an emerging method to quantify liver function and can serve as a potential alternative to hepatobiliary scintigraphy. • Assessment of liver function with dynamic gadoxetate-enhanced MRI is comparable with that of hepatobiliary scintigraphy and has the potential to be combined with diagnostic MRI imaging.

SUBMITTER: Rassam F

PROVIDER: S-EPMC6682576 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Comparison between dynamic gadoxetate-enhanced MRI and <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Rassam F F Zhang T T Cieslak K P KP Lavini C C Stoker J J Bennink R J RJ van Gulik T M TM van Vliet L J LJ Runge J H JH Vos F M FM

European radiology 20190222 9

<h4>Objectives</h4>To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection.<h4>Methods</h4>Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using <sup>99m</sup>Tc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake funct ...[more]

PMID: 30796575

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Project description:ObjectivesTo compare the dynamic changes in future liver remnant (FLR) function and volume after hepatectomy and to evaluate the associations between three modalities in assessment of liver function.MethodsLiver function and volume were quantified pre-operatively, at post-operative day (POD) 7 and POD 28 in 10 patients with colorectal liver metastases undergoing hemihepatectomy using the indocyanine green retention (ICG) test, hepatobiliary scintigraphy (HBS) and gadoxetic acid-enhanced MRI. The 99mTc mebrofenin uptake rate in the FLR was applied as a reference of liver function. MRI-derived parameters including liver-to-muscle ratio (LMR), liver-to-spleen ratio (LSR) and hepatocellular uptake index (HUI) were used for liver function assessment. Spearman's correlation analysis was used to evaluate the associations.ResultsIncrease in liver function ranged from 13 to 152% (median 92%) and in volume from 37 to 134% (median 79%). There was no significant discrepancy in increase between FLR function and volume during the first month following hepatectomy. LMR showed a significant correlation to ICG test (r = -0.66, p < 0.05) while LSR had an association with standardized FLR function obtained by HBS (r = -0.71, p < 0.05). During the first week after hepatectomy, pre-operative HUI and LMR showed the strongest correlation to the FLR growth in function and volume respectively (p < 0.05).ConclusionThe observed growth in FLR volume is closely related to the functional increase within 1 month after hepatectomy. Gadoxetic acid-enhanced MRI might substitute HBS for regional liver function assessment and provide an imaging tool for liver growth prediction.Advances in knowledgeLiver function growth was parallel with liver volume increase during the perioperative period. Liver function assessment with gadoxetic acid-enhanced MRI was comparable with that of HBS indicating that gadoxetic acid-enhanced MRI could substitute HBS for regional liver function evaluation.

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Dataset Information

Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Objectives

Methods

Results

Key points

Publications

Comparison between dynamic gadoxetate-enhanced MRI and <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Comparison between dynamic gadoxetate-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Objectives

Methods

Results

Key points

Publications

Comparison between dynamic gadoxetate-enhanced MRI and <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.