Dataset Information

Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

ABSTRACT:

Objectives

To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with ^99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection.

Methods

Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using ^99mTc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake function was calculated for both modalities: mebrofenin uptake rate (MUR) and Ki respectively. The FRL was delineated with both SPECT-CT and MRI to calculate the functional share. Blood samples were taken to assess biochemical liver parameters.

Results

A total of 20 patients were included. The HBS-derived MUR and the DHCE-MRI-derived mean Ki correlated strongly for both total and FRL function (Pearson r?=?0.70, p?=?0.001 and r?=?0.89, p?ConclusionsAssessment of liver function with DHCE-MRI is comparable with that of ^99mTc-mebrofenin HBS and has the potential to be combined with diagnostic MRI imaging. This can therefore provide a one-stop-shop modality for the preoperative assessment of patients undergoing liver surgery.

Key points

• Quantitative assessment of liver function using hepatobiliary scintigraphy is performed in the preoperative assessment of patients undergoing liver surgery in order to prevent posthepatectomy liver failure. • Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) is an emerging method to quantify liver function and can serve as a potential alternative to hepatobiliary scintigraphy. • Assessment of liver function with dynamic gadoxetate-enhanced MRI is comparable with that of hepatobiliary scintigraphy and has the potential to be combined with diagnostic MRI imaging.

SUBMITTER: Rassam F

PROVIDER: S-EPMC6682576 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Comparison between dynamic gadoxetate-enhanced MRI and <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Rassam F F Zhang T T Cieslak K P KP Lavini C C Stoker J J Bennink R J RJ van Gulik T M TM van Vliet L J LJ Runge J H JH Vos F M FM

European radiology 20190222 9

<h4>Objectives</h4>To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection.<h4>Methods</h4>Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using <sup>99m</sup>Tc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake funct ...[more]

PMID: 30796575

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Dataset Information

Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Objectives

Methods

Results

Key points

Publications

Comparison between dynamic gadoxetate-enhanced MRI and <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Comparison between dynamic gadoxetate-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Objectives

Methods

Results

Key points

Publications

Comparison between dynamic gadoxetate-enhanced MRI and <sup>99m</sup>Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.