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Triple-negative breast cancer: current perspective on the evolving therapeutic landscape.


ABSTRACT: Triple-negative breast cancer (TNBC) is known to have a poor prognosis and limited treatment options, namely chemotherapy. Different molecular studies have recently classified TNBC into different subtypes opening the door to potential new-targeted treatment options. In this review, we discuss the current standard of care in the treatment of TNBC in the neoadjuvant, adjuvant and metastatic settings. In addition, we summarize the ongoing phase III clinical trials evaluating different associations between the 3 pillars of anticancer treatment: chemotherapy, targeted therapy and immunotherapy.

SUBMITTER: Mehanna J 

PROVIDER: S-EPMC6682754 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Triple-negative breast cancer: current perspective on the evolving therapeutic landscape.

Mehanna Joe J   Haddad Fady Gh FG   Eid Roland R   Lambertini Matteo M   Kourie Hampig Raphael HR  

International journal of women's health 20190731


Triple-negative breast cancer (TNBC) is known to have a poor prognosis and limited treatment options, namely chemotherapy. Different molecular studies have recently classified TNBC into different subtypes opening the door to potential new-targeted treatment options. In this review, we discuss the current standard of care in the treatment of TNBC in the neoadjuvant, adjuvant and metastatic settings. In addition, we summarize the ongoing phase III clinical trials evaluating different associations  ...[more]

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