Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma.
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ABSTRACT:
SUBMITTER: Thielmann CM
PROVIDER: S-EPMC6683135 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma.
Thielmann Carl Maximilian CM Costa da Silva Milene M Muley Thomas T Meister Michael M Herpel Esther E Muckenthaler Martina U MU
Scientific reports 20190805 1
Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, pa ...[more]
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