Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

ABSTRACT: Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (n?=?154), (2) sporadic CLL (n?=?302), (3) familial MBL (n?=?87), (4) unaffected first-degree relatives from CLL/MBL families (n?=?263), and (5) reference population (n?=?15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (p's??0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (p's?

SUBMITTER: Clay-Gilmour AI 

PROVIDER: S-EPMC6683199 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature