Dataset Information

Genes and Elite Marathon Running Performance: A Systematic Review.

ABSTRACT: Genetics has long been considered to associate with many exercise-related traits and sport performance phenotypes. A genetic basis for elite international marathon running performance exists due to the heritability of endurance-related traits. This has prompted a generation of genomic study to identify marathon success. The aim of this study was to systematically review the evidence of genes, and their polymorphisms, that may play a role in marathon running performance. A search strategy was implemented on systematic databases following PRISMA guidelines. Studies were case-control, cohort or genome-wide association designs and provided data on the genotypes associated with elite marathon athlete status and/or marathon running performance. The search identified 241 studies, from which, 14 studies were deemed suitable for inclusion. A total of 160 different polymorphisms in 27 genes were identified in 10,442 participants, of which 2,984 were marathon distance runners. The review identified a possible 16 single nucleotide polymorphisms (SNPs) in 14 genes associated with marathon running performance. While multiple genes and their polymorphisms have been associated with marathon running performance, predicting future marathon success based on genomic data is premature due to the lack of replicated studies. There is limited replication of genotype-phenotype associations and there is possible publication bias, thus, further studies are required to strengthen our understanding of the genes involved in marathon running. Future research utilising genome-wide technologies in large cohorts is required to elucidate the multiple genetic factors that govern complex endurance-related traits and the impact of epigenetics should be considered.

SUBMITTER: Moir HJ

PROVIDER: S-EPMC6683622 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Genes and Elite Marathon Running Performance: A Systematic Review.

Moir Hannah J HJ Kemp Rachael R Folkerts Dirk D Spendiff Owen O Pavlidis Cristina C Opara Elizabeth E

Journal of sports science & medicine 20190801 3

Genetics has long been considered to associate with many exercise-related traits and sport performance phenotypes. A genetic basis for elite international marathon running performance exists due to the heritability of endurance-related traits. This has prompted a generation of genomic study to identify marathon success. The aim of this study was to systematically review the evidence of genes, and their polymorphisms, that may play a role in marathon running performance. A search strategy was imp ...[more]

PMID: 31427879

Similar Datasets

Project description:BACKGROUND:Replication studies are essential for identifying credible associations between alleles and phenotypes. Validation of genotype-phenotype associations in the sports and exercise field is rare. An initial genetic association study suggested that rs1049305 (C > G) in the 3' untranslated region (3'UTR) of the aquaporin-1 (AQP1) gene was associated with marathon running (MR) performance level in Hispanic males. To validate this finding, we conducted a replication analysis in an independent case-control sample of Hispanic male marathon runners (n = 1430; cases n = 713 and controls n = 717). A meta-analysis was utilized to test the extent of the association between the initial results and the present report. It also provided to test the heterogeneity (variation) between the two studies. RESULTS:The replication study showed a statistically significant (p ? 0.05) association between rs1049305 (C > G) of the AQP1 gene and MR performance level. Association test results using a fixed effect model for the combined, original study and the present report, yielded an odds ratio = 1.28, 95% confidence interval = 1.13-1.45, p = 0.0001. The extent of the measures of heterogeneity was Tau-squared = 0, H statistic = 1, I2 statistic = 0, and Cochran's Q test (Q = 0.29; p value 0.59), indicated the variation between studies were due to chance and not to differences in heterogeneity between the two studies. Within the limitations of the present replication, contrast of two studies and its effects on meta-analysis, the findings were robust. CONCLUSION:This study successfully replicated the results of Martínez et al. (Med Sportiva 13:251-5, 2009). The meta-analysis provided further epidemiological credibility for the hypothesis of association between the DNA rs1049305 (C > G) variation in the 3'UTR of the AQP1 gene and MR running performance level in Hispanics male marathon runners. It is not precluded that a linked DNA structure in the surrounding molecular neighborhood could be of influence by been part of the overly complex phenotype of MR performance level.

Project description:Background: In elite athletes, training individualization is widely recommended to optimize competitive performance. Previous studies have evidenced the impact of hormonal fluctuations on different performance parameters among female athletes. While consideration of menstrual cycle (MC) phases as a parameter in training individualization strategies is necessary, systematic evidence identifying such impacts in elite athletes should be evaluated. Objective: Systematically review publications that have investigated the link between MC phases and performance in elite female athletes. The overarching aim is to identify whether a consensus across studies exists enabling evidence-based recommendations for training individualization depending on menstrual cycle phases. Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Three major scientific publication databases were searched from inception until November 3, 2020. Studies included focused on the influence of physiological or psychological parameters throughout at least one phase of the menstrual cycle of elite athletes. Results: A total of 780 search results were yielded and 26 references from a past bibliography were added manually. About 662 papers were reviewed of which 218 studies were assessed for eligibility. Of these, only seven (1%) precisely investigated the influence of a performance or physical parameter during at least one menstrual cycle phase. These seven studies included a total of 314 elite female participants (20.58 ± 1.91 years). Three used interviews, questionnaires or prospective analyses of reports. Four conducted several performance tests or included physical measures although only two performed tests during training or before/during competition. Among the seven studies, five performed hormonal testing through sampling of blood, saliva, or urine. The remaining relied on athletes' menstruation diaries. The current evidence suggests a variable association between menstrual cycle and a few performance-related outcomes, such as endurance or power resistance, ligament stiffness, decision making skills, psychology, or competitiveness. Conclusion: Different sports performance-related parameters are affected during the menstrual cycle among elite athletes, but the parameters themselves and the magnitude and the direction of the effects are inconclusive. Additional longitudinal and prospective studies to systematically monitor on-field performance parameters are urgently required in order to enable recommendations and training individualization in female elite athletes.

Dataset Information

Genes and Elite Marathon Running Performance: A Systematic Review.

Publications

Genes and Elite Marathon Running Performance: A Systematic Review.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets