Ontology highlight
ABSTRACT:
SUBMITTER: Brand GD
PROVIDER: S-EPMC6684085 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Brand Guilherme D GD Ramada Marcelo H S MHS Manickchand Júlia R JR Correa Rafael R Ribeiro Dalila J S DJS Santos Michele A MA Vasconcelos Andreanne G AG Abrão Fernando Y FY Prates Maura V MV Murad André M AM Cardozo Fh José L JL Leite José Roberto S A JRSA Magalhães Kelly G KG Oliveira Aline L AL Bloch Carlos C
PloS one 20190806 8
Following the treads of our previous works on the unveiling of bioactive peptides encrypted in plant proteins from diverse species, the present manuscript reports the occurrence of four proof-of-concept intragenic antimicrobial peptides in human proteins, named Hs IAPs. These IAPs were prospected using the software Kamal, synthesized by solid phase chemistry, and had their interactions with model phospholipid vesicles investigated by differential scanning calorimetry and circular dichroism. Thei ...[more]