Ontology highlight
ABSTRACT:
SUBMITTER: Ratliff WA
PROVIDER: S-EPMC6684170 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Journal of molecular neuroscience : MN 20180813 1
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disease for which there is currently no effective treatment. The progression of ALS includes loss of motor neurons controlling the voluntary muscles, with much of this loss occurring at the neuromuscular junction. In an effort to better understand changes at the neuromuscular junction, we utilized the wobbler mouse model of motor neuron loss. We examined biceps and end plate morphologies and monitored selected facto ...[more]