Ontology highlight
ABSTRACT:
SUBMITTER: Gottschalk RA
PROVIDER: S-EPMC6684266 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Gottschalk Rachel A RA Dorrington Michael G MG Dutta Bhaskar B Krauss Kathleen S KS Martins Andrew J AJ Uderhardt Stefan S Chan Waipan W Tsang John S JS Torabi-Parizi Parizad P Fraser Iain Dc ID Germain Ronald N RN
eLife 20190806
Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined. By stimulating mouse macrophages with a titration matrix of TLR ligand pairs, we identified distinct stimulus requirements for activating and inhibitory events that evoked diverse cytokine production dynamics. These regulatory events were linked to patterns of inflammatory respons ...[more]