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Rate of change in body mass index at different ages during childhood and adult obesity risk.


ABSTRACT: BACKGROUND:Childhood body mass index (BMI) predicts adult obesity. How growth trajectories during childhood relate to adult obesity risk is not well defined. OBJECTIVE:We aimed to characterize BMI growth trajectories from childhood to midlife and to examine the associations between BMI growth rates at childhood age points and adult obesity risk. METHODS:The longitudinal study included 2732 participants with repeated BMI measurements from childhood (4-19 y) to adulthood (20-51 y). A random-effects model was used to construct BMI growth curves by race and sex. Model-estimated levels and linear growth rates of BMI were linked to adult obesity in separate multivariable logistic regression models at individual childhood age points. RESULTS:BMI followed cubic growth curves. Childhood BMI linear slope estimates were higher in adults with obesity than in adults without obesity (P < 0.001). The association between childhood BMI growth rate and adult obesity was significantly higher in puberty and postpuberty (12-19 y) than in early childhood (4-11 y) with a peak at age 14 (odds ratio = 3.1 and 95% confidence interval, 2.7-3.5). CONCLUSIONS:Rates of change in BMI at different childhood ages are differentially associated with adult obesity. Puberty and postpuberty are crucial periods for the development of obesity in later life.

SUBMITTER: Zhang T 

PROVIDER: S-EPMC6684349 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Rate of change in body mass index at different ages during childhood and adult obesity risk.

Zhang Tao T   Whelton Paul K PK   Xi Bo B   Krousel-Wood Marie M   Bazzano Lydia L   He Jiang J   Chen Wei W   Li Shengxu S  

Pediatric obesity 20190131 7


<h4>Background</h4>Childhood body mass index (BMI) predicts adult obesity. How growth trajectories during childhood relate to adult obesity risk is not well defined.<h4>Objective</h4>We aimed to characterize BMI growth trajectories from childhood to midlife and to examine the associations between BMI growth rates at childhood age points and adult obesity risk.<h4>Methods</h4>The longitudinal study included 2732 participants with repeated BMI measurements from childhood (4-19 y) to adulthood (20-  ...[more]

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