Ontology highlight
ABSTRACT:
SUBMITTER: Heybrock S
PROVIDER: S-EPMC6684646 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Heybrock Saskia S Kanerva Kristiina K Meng Ying Y Ing Chris C Liang Anna A Xiong Zi-Jian ZJ Weng Xialian X Ah Kim Young Y Collins Richard R Trimble William W Pomès Régis R Privé Gilbert G GG Annaert Wim W Schwake Michael M Heeren Joerg J Lüllmann-Rauch Renate R Grinstein Sergio S Ikonen Elina E Saftig Paul P Neculai Dante D
Nature communications 20190806 1
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in SR-B1 that mediates lipid transfer. The detection of cholesterol within the LIMP-2 structure and the formation of cholesterol<sup>-</sup>like inclusions in LIMP-2 knockout mice suggested the possibility that LIMP2 transports cholesterol in lysosomes. ...[more]