Ontology highlight
ABSTRACT:
SUBMITTER: Dragset MS
PROVIDER: S-EPMC6684656 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Dragset Marte S MS Ioerger Thomas R TR Zhang Yanjia J YJ Mærk Mali M Ginbot Zekarias Z Sacchettini James C JC Flo Trude H TH Rubin Eric J EJ Steigedal Magnus M
Scientific reports 20190806 1
Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and categorize mycobacterial genes required for low iron fitness. Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), can scavenge host-sequestered iron by high-aff ...[more]