Ontology highlight
ABSTRACT:
SUBMITTER: La Rosa P
PROVIDER: S-EPMC6685360 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
La Rosa Piergiorgio P Russo Marta M D'Amico Jessica J Petrillo Sara S Aquilano Katia K Lettieri-Barbato Daniele D Turchi Riccardo R Bertini Enrico S ES Piemonte Fiorella F
Frontiers in cellular neuroscience 20190731
Frataxin deficiency is the pathogenic cause of Friedreich's Ataxia, an autosomal recessive disease characterized by the increase of oxidative stress and production of free radicals in the cell. Although the onset of the pathology occurs in the second decade of life, cognitive differences and defects in brain structure and functional activation are observed in patients, suggesting developmental defects to take place during fetal neurogenesis. Here, we describe impairments in proliferation, stemne ...[more]