Ontology highlight
ABSTRACT:
SUBMITTER: Chia K
PROVIDER: S-EPMC6685703 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Chia Kelda K Keatinge Marcus M Mazzolini Julie J Sieger Dirk D
eLife 20190717
Previously we described direct cellular interactions between microglia and AKT1+ brain tumour cells in zebrafish (Chia et al., 2018). However, it was unclear how these interactions were initiated: it was also not clear if they had an impact on the growth of tumour cells. Here, we show that neoplastic cells hijack mechanisms that are usually employed to direct microglial processes towards highly active neurons and injuries in the brain. We show that AKT1+ cells possess dynamically regulated high ...[more]