Ontology highlight
ABSTRACT:
SUBMITTER: Nam S
PROVIDER: S-EPMC6685709 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nam Sungmin S Gupta Vivek Kumar VK Lee Hong-Pyo HP Lee Joanna Y JY Wisdom Katrina M KM Varma Sushama S Flaum Eliott Marie EM Davis Ciara C West Robert B RB Chaudhuri Ovijit O
Science advances 20190807 8
In tissues, cells reside in confining microenvironments, which may mechanically restrict the ability of a cell to double in size as it prepares to divide. How confinement affects cell cycle progression remains unclear. We show that cells progressed through the cell cycle and proliferated when cultured in hydrogels exhibiting fast stress relaxation but were mostly arrested in the G<sub>0</sub>/G<sub>1</sub> phase of the cell cycle when cultured in hydrogels that exhibit slow stress relaxation. In ...[more]