The spectrum of spinal cord lesions in a primate model of multiple sclerosis.
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ABSTRACT:
SUBMITTER: Lefeuvre JA
PROVIDER: S-EPMC6685769 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
The spectrum of spinal cord lesions in a primate model of multiple sclerosis.
Lefeuvre Jennifer A JA Guy Joseph R JR Luciano Nicholas J NJ Ha Seung-Kwon SK Leibovitch Emily E Santin Mathieu D MD Silva Afonso C AC Jacobson Steven S Lehéricy Stéphane S Reich Daniel S DS Sati Pascal P
Multiple sclerosis (Houndmills, Basingstoke, England) 20190207 3
<h4>Background</h4>Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage.<h4>Objective</h4>To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histo ...[more]
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