Ontology highlight
ABSTRACT:
SUBMITTER: Rubies C
PROVIDER: S-EPMC6685984 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Rubies Cira C Dantas Ana-Paula AP Batlle Montserrat M Torres Marta M Farre Ramon R Sangüesa Gemma G Montserrat Josep M JM Mont Lluis L Almendros Isaac I Guasch Eduard E
Scientific reports 20190807 1
Obstructive sleep apnea syndrome (OSA) promotes aortic dilatation, increased stiffness and accelerated atherosclerosis, but the mechanisms of vascular remodelling are not known. We aimed to assess vascular remodelling, its mechanisms, and the effect of mesenchymal stem cells (MSC) infusions in a clinically relevant rat model of chronic OSA involving recurrent airway obstructions leading thoracic pressure swings and intermittent hypoxia/hypercapnia (OSA-rats). Another group of rats were placed in ...[more]