Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC6686169 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Chen Jian J Mei Zhengfeng Z Huang Bao B Zhang Xuyang X Liu Junhui J Shan Zhi Z Wang Jiasheng J Wang Xianjun X Zhao Fengdong F
Journal of cellular physiology 20181203 5
Yes-associated protein 1 (YAP1) is a transcriptional coactivator and negative regulator of the Hippo pathway. It regulates diverse cellular processes, such as cell proliferation, contact inhibition, and tissue size. However, the role of YAP1 in intervertebral disc degeneration (IDD) remains elusive. Here, we demonstrated that YAP1 was activated by Interleukin 6 (IL-6) through tyrosine phosphorylation in nucleus pulposus cells (NP cells). Overexpression of YAP1 decreased Sox-9, Col-II, aggrecan e ...[more]