The prognostic value of lncRNA SNHG1 in cancer patients: a meta-analysis.

ABSTRACT:

Background

Increasing evidence revealed that high expression level of lncRNA SNHG1 was associated with the unfavorable prognosis of cancer and maybe used as a valuable biomarker for cancer patients. The present meta->analysis is to analyze existing data to reveal potential clinical application of SNHG1 on cancer prognosis and tumor progression. All of the included studies were collected through a variety of retrieval strategies. And the articles were qualified by MOOSE and PRISMA checklists.

Methods

Up to Mar 20, 2018, literature collection was performed by comprehensive search through electronic databases, including the Cochrane library, PubMed, Embase, Web of science, Springer, Science direct, and three Chinese databases: CNKI, Weipu, and Wanfang. We analyzed 14?studies that met the criteria, and concluded that the increased SHNG1 level was correlated with poor OS and tumor progression.

Results

The combined results indicated that elevated SNHG1 expression level was significantly associated with poor OS (HR?=?2.06, 95% CI: 1.69-2.52, P ConclusionsThe present analysis indicated that the increased SNHG1 is associated with poor OS in patients with general tumors and may be served as a useful prognostic biomarker.

SUBMITTER: Dong B 

PROVIDER: S-EPMC6686246 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature