Examining the causal role of leptin in bone mineral density: A Mendelian randomization study.
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ABSTRACT:
SUBMITTER: Meng XH
PROVIDER: S-EPMC6686663 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Examining the causal role of leptin in bone mineral density: A Mendelian randomization study.
Meng Xiang-He XH Tan Li-Jun LJ Xiao Hong-Mei HM Tang Bei-Sha BS Deng Hong-Wen HW
Bone 20190508
Leptin, a small polypeptide hormone secreted by the adipocytes, controls body weight and gonadal function by binding to a special receptor located in the hypothalamus. Observational studies have demonstrated a controversial association between leptin and bone mineral density (BMD), and functional studies of the relationship between leptin and BMD still largely vary by different studies. Using SNPs strongly associated with leptin levels in 52,140 individuals, we conducted a two-sample Mendelian r ...[more]
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