Unknown

Dataset Information

0

Towards a Scalable Synthesis of 2-Oxabicyclo[2.2.0]hex-5-en-3-one Using Flow Photochemistry.


ABSTRACT: Cyclobutene lactones hold great potential as synthetic building blocks, yet their preparation by photochemical rearrangement in batch can often be a bottleneck in synthetic studies. We report the use of flow photochemistry as a tool to enable a higher-throughput approach to the synthesis of 2-oxabicyclo[2.2.0]hex-5-en-3-one, which reduces reaction times from 24 h to 10 min. Accordingly, a significantly improved throughput of 144 mg/h (vs 14-21 mg/h in batch) was achieved. Scale-out experiments showed problematic reactor fouling and steps were taken to explore and minimize this effect.

SUBMITTER: Williams JD 

PROVIDER: S-EPMC6686974 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3344021 | biostudies-literature
| S-EPMC3089366 | biostudies-literature
| S-EPMC2959380 | biostudies-literature
| S-EPMC3100040 | biostudies-literature
| S-EPMC3393964 | biostudies-literature
| S-EPMC3200777 | biostudies-literature
| S-EPMC3275037 | biostudies-literature
| S-EPMC3201272 | biostudies-literature
| S-EPMC3200708 | biostudies-literature
| S-EPMC6943495 | biostudies-literature