Ontology highlight
ABSTRACT:
SUBMITTER: Kanayama T
PROVIDER: S-EPMC6687107 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kanayama Tomohiro T Tomita Hiroyuki H Binh Nguyen Huy NH Hatano Yuichiro Y Aoki Hitomi H Okada Hideshi H Hirata Akihiro A Fujihara Yoshitaka Y Kunisada Takahiro T Hara Akira A
PloS one 20190808 8
Cytokeratin 19 (KRT19) protein is highly expressed in the epithelium of the gastrointestinal (GI) tract, hepatobiliary tissues, and pancreas of humans and mice. In the present study, we used an improved Cre (iCre) gene to enhance the efficiency of Cre expression in mammalian cells. We established a new transgenic Krt19-iCre bacterial artificial chromosome (BAC) mouse model using the BAC recombineering strategy. Site-specific iCre expression pattern was examined in embryos, adults, and elderly Kr ...[more]