Ontology highlight
ABSTRACT:
SUBMITTER: Arango Duque G
PROVIDER: S-EPMC6687203 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Arango Duque Guillermo G Jardim Armando A Gagnon Étienne É Fukuda Mitsunori M Descoteaux Albert A
PLoS pathogens 20190729 7
To colonize phagocytes, Leishmania subverts microbicidal processes through components of its surface coat that include lipophosphoglycan and the GP63 metalloprotease. How these virulence glycoconjugates are shed, exit the parasitophorous vacuole (PV), and traffic within host cells is poorly understood. Here, we show that lipophosphoglycan and GP63 are released from the parasite surface following phagocytosis and redistribute to the endoplasmic reticulum (ER) of macrophages. Pharmacological disru ...[more]