Ontology highlight
ABSTRACT:
SUBMITTER: Manduchi E
PROVIDER: S-EPMC6687530 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Manduchi Elisabetta E Hemerich Daiane D van Setten Jessica J Tragante Vinicius V Harakalova Magdalena M Pei Jiayi J Williams Scott M SM van der Harst Pim P Asselbergs Folkert W FW Moore Jason H JH
Genetic epidemiology 20190530 6
A typical task arising from main effect analyses in a Genome Wide Association Study (GWAS) is to identify single nucleotide polymorphisms (SNPs), in linkage disequilibrium with the observed signals, that are likely causal variants and the affected genes. The affected genes may not be those closest to associating SNPs. Functional genomics data from relevant tissues are believed to be helpful in selecting likely causal SNPs and interpreting implicated biological mechanisms, ultimately facilitating ...[more]