Ontology highlight
ABSTRACT:
SUBMITTER: McNeer NA
PROVIDER: S-EPMC6687545 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
McNeer Nicole A NA Philip John J Geiger Heather H Ries Rhonda E RE Lavallée Vincent-Philippe VP Walsh Michael M Shah Minita M Arora Kanika K Emde Anne-Katrin AK Robine Nicolas N Alonzo Todd A TA Kolb E Anders EA Gamis Alan S AS Smith Malcolm M Gerhard Daniela Se DS Guidry-Auvil Jaime J Meshinchi Soheil S Kentsis Alex A
Leukemia 20190213 8
Acute myeloid leukemias (AML) are characterized by mutations of tumor suppressor and oncogenes, involving distinct genes in adults and children. While certain mutations have been associated with the increased risk of AML relapse, the genomic landscape of primary chemotherapy-resistant AML is not well defined. As part of the TARGET initiative, we performed whole-genome DNA and transcriptome RNA and miRNA sequencing analysis of pediatric AML with failure of induction chemotherapy. We identified at ...[more]