Ontology highlight
ABSTRACT:
SUBMITTER: Bonkhofer F
PROVIDER: S-EPMC6687740 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Bonkhofer Florian F Rispoli Rossella R Pinheiro Philip P Krecsmarik Monika M Schneider-Swales Janina J Tsang Ingrid Ho Ching IHC de Bruijn Marella M Monteiro Rui R Peterkin Tessa T Patient Roger R
Nature communications 20190808 1
Haematopoietic stem cells are generated from the haemogenic endothelium (HE) located in the floor of the dorsal aorta (DA). Despite being integral to arteries, it is controversial whether HE and arterial endothelium share a common lineage. Here, we present a transgenic zebrafish runx1 reporter line to isolate HE and aortic roof endothelium (ARE)s, excluding non-aortic endothelium. Transcriptomic analysis of these populations identifies Runx1-regulated genes and shows that HE initially expresses ...[more]