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Association between tumor necrosis factor-? and chronic obstructive pulmonary disease: a systematic review and meta-analysis.

ABSTRACT: BACKGROUND:Patients diagnosed with chronic obstructive pulmonary disease (COPD) have increased risks for a series of physical and mental illnesses. Tumor necrosis factor-? (TNF-?) has been reported to participate in the development of COPD and its complications. However, the values of blood TNF-? level used in the diagnosis of COPD remains controversial. In view of this, we performed a systematic review and meta-analysis to evaluate the correlation between TNF-? level and COPD. METHODS:We searched PubMed, Web of Science, Embase and CNKI up to May 2018. The selection criteria were set according to the PICOS framework. A random-effects model was then applied to evaluate the overall effect sizes by calculating standard mean difference (SMD) and its 95% confidence intervals (CIs). RESULTS:A total of 40 articles containing 4189 COPD patients and 1676 healthy controls were included in this meta-analysis. The results indicated a significant increase in TNF-? level in the COPD group compared with the control group (SMD: 1.24, 95% CI: 0.78-1.71, p?

SUBMITTER: Yao Y 

PROVIDER: S-EPMC6688146 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature

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Association between tumor necrosis factor-α and chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Yao Yang Y   Zhou Jing J   Diao Xin X   Wang Shengyu S  

Therapeutic advances in respiratory disease 20190101

<h4>Background</h4>Patients diagnosed with chronic obstructive pulmonary disease (COPD) have increased risks for a series of physical and mental illnesses. Tumor necrosis factor-α (TNF-α) has been reported to participate in the development of COPD and its complications. However, the values of blood TNF-α level used in the diagnosis of COPD remains controversial. In view of this, we performed a systematic review and meta-analysis to evaluate the correlation between TNF-α level and COPD.<h4>Method  ...[more]

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