Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity.
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ABSTRACT:
SUBMITTER: Lacombe J
PROVIDER: S-EPMC6688300 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity.
Lacombe Jérôme J Brengues Muriel M Mangé Alain A Bourgier Céline C Gourgou Sophie S Pèlegrin André A Ozsahin Mahmut M Solassol Jérôme J Azria David D
Radiation oncology (London, England) 20190809 1
<h4>Background</h4>Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conversely, proteomics approaches are not much developed, despite their advantages.<h4>Methods</h4>We used the isobaric tags for relative and absolute quantitation (iTRAQ) proteomic approach to analyze differences in protein expression levels in ex-vivo irradiated (8 Gy) T ly ...[more]
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