Dataset Information

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index　- The INTERLIPID Study.

ABSTRACT:

Background

Recently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors. Methods and Results: We examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40-59 years in 1996-1998. Participants treated for dyslipidemias were excluded. Lifestyle factors included alcohol intake, smoking amount, and body mass index (BMI). Multivariable linear regression was used for cross-sectional analyses of these factors with HDL-P, HDL-C, HDL-P size subclasses (small, medium and large) and mean HDL-P size. In men, higher alcohol intake was associated with higher HDL-P and higher HDL-C. The associations of alcohol, however, were strongest with HDL-P. A higher smoking amount tended to be associated with lower HDL-P and HDL-C. In contrast, BMI was not associated with HDL-P, but was strongly inversely associated with HDL-C. While alcohol intake favored larger mean HDL-P size, smoking and BMI favored a lipid profile with smaller HDL-P subclasses and overall smaller mean HDL-P size. Similar, but generally weaker results were observed in women.

Conclusions

Although both HDL-P and HDL-C are parameters of HDL, they have different associations with alcohol, smoking and BMI.

SUBMITTER: Zaid M

PROVIDER: S-EPMC6688485 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index　- The INTERLIPID Study.

Zaid Maryam M Miura Katsuyuki K Okayama Akira A Nakagawa Hideaki H Sakata Kiyomi K Saitoh Shigeyuki S Okuda Nagako N Yoshita Katsushi K Choudhury Sohel R SR Rodriguez Beatriz B Masaki Kamal K Willcox Bradley B Miyagawa Naoko N Okamura Tomonori T Chan Queenie Q Elliott Paul P Stamler Jeremiah J Ueshima Hirotsugu H

Circulation journal : official journal of the Japanese Circulation Society 20180821 10

<h4>Background</h4>Recently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors.<h4>Methods and results</h4>We examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40-59 yea ...[more]

PMID: 30135319

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Dataset Information

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index　- The INTERLIPID Study.

Background

Conclusions

Publications

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index　- The INTERLIPID Study.

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OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index - The INTERLIPID Study.

Background

Conclusions

Publications

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index - The INTERLIPID Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index　- The INTERLIPID Study.

Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index　- The INTERLIPID Study.