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Solventless and Metal-free Regioselective Hydrofluorination of Functionalized Alkynes and Allenes: An Efficient Protocol for the Synthesis of gem-Difluorides.


ABSTRACT: The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO4-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce gem-difluorides with high atom economy, and with an easy workup.

SUBMITTER: Lu Z 

PROVIDER: S-EPMC6688647 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Solventless and Metal-free Regioselective Hydrofluorination of Functionalized Alkynes and Allenes: An Efficient Protocol for the Synthesis of <i>gem</i>-Difluorides.

Lu Zhichao Z   Bajwa Bhvandip S BS   Liu Shiwen S   Lee Sheye S   Hammond Gerald B GB   Xu Bo B  

Green chemistry : an international journal and green chemistry resource : GC 20190215 6


The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO<sub>4</sub>-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce <i>gem</i>-difluorides with high atom economy, and with an easy workup. ...[more]

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