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Solventless and Metal-free Regioselective Hydrofluorination of Functionalized Alkynes and Allenes: An Efficient Protocol for the Synthesis of gem-Difluorides.

ABSTRACT: The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO4-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce gem-difluorides with high atom economy, and with an easy workup.

SUBMITTER: Lu Z

PROVIDER: S-EPMC6688647 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Solventless and Metal-free Regioselective Hydrofluorination of Functionalized Alkynes and Allenes: An Efficient Protocol for the Synthesis of gem-Difluorides.

Lu Zhichao Z Bajwa Bhvandip S BS Liu Shiwen S Lee Sheye S Hammond Gerald B GB Xu Bo B

Green chemistry : an international journal and green chemistry resource : GC 20190215 6

The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO4-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce gem-difluorides with high atom economy, and with an easy workup. ...[more]

PMID: 31404296

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