Ontology highlight
ABSTRACT:
SUBMITTER: Puleston DJ
PROVIDER: S-EPMC6688828 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Puleston Daniel J DJ Buck Michael D MD Klein Geltink Ramon I RI Kyle Ryan L RL Caputa George G O'Sullivan David D Cameron Alanna M AM Castoldi Angela A Musa Yaarub Y Kabat Agnieszka M AM Zhang Ying Y Flachsmann Lea J LJ Field Cameron S CS Patterson Annette E AE Scherer Stefanie S Alfei Francesca F Baixauli Francesc F Austin S Kyle SK Kelly Beth B Matsushita Mai M Curtis Jonathan D JD Grzes Katarzyna M KM Villa Matteo M Corrado Mauro M Sanin David E DE Qiu Jing J Pällman Nora N Paz Katelyn K Maccari Maria Elena ME Blazar Bruce R BR Mittler Gerhard G Buescher Joerg M JM Zehn Dietmar D Rospert Sabine S Pearce Edward J EJ Balabanov Stefan S Pearce Erika L EL
Cell metabolism 20190523 2
How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5A<sup>H</sup>) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS). Several of these proteins have mitochondrial targeting sequences (MTSs ...[more]