Integrative analysis of the intestinal metabolome of childhood asthma.

ABSTRACT:

Background

The intestinal metabolome reflects the biological consequences of diverse exposures and might provide insight into asthma pathophysiology.

Objective

We sought to perform an untargeted integrative analysis of the intestinal metabolome of childhood asthma in this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial.

Methods

Metabolomic profiling was performed by using mass spectrometry on fecal samples collected from 361 three-year-old subjects. Adjusted logistic regression analyses identified metabolites and modules of highly correlated metabolites associated with asthma diagnosis by age 3 years. Sparse canonical correlation analysis identified associations relevant to asthma between the intestinal metabolome and other "omics": the intestinal mi

SUBMITTER: Lee-Sarwar KA 

PROVIDER: S-EPMC6688902 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature