Ontology highlight
ABSTRACT:
SUBMITTER: Huang T
PROVIDER: S-EPMC6688996 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Huang Tianlu T Ding Xiwei X Xu Guifang G Chen Gang G Cao Yu Y Peng Chunyan C Shen Shanshan S Lv Ying Y Wang Lei L Zou Xiaoping X
Cell death & disease 20190809 8
Cholangiocarcinoma (CCA) is a fatal disease without effective targeted therapy. We screened a small-molecule library of 116 inhibitors targeting different targets of the cell cycle and discovered several kinases, including Cyclin-dependent kinase 7 (CDK7) as vulnerabilities in CCA. Analysis of multiple CCA data sets demonstrated that CDK7 was overexpressed in CCA tissues. Further studies demonstrated that CDK7 inhibitor THZ1 inhibited cell viability and induced apoptosis in CCA cells. We also sh ...[more]