Ontology highlight
ABSTRACT:
SUBMITTER: Honda A
PROVIDER: S-EPMC6689013 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Honda Arata A Tachibana Ryoma R Hamada Kazuya K Morita Kohtaro K Mizuno Naoaki N Morita Kento K Asano Masahide M
Scientific reports 20190809 1
Rats are effective model animals and have contributed to the development of human medicine and basic research. However, the application of reproductive engineering techniques to rats is not as advanced compared with mice, and genome editing in rats has not been achieved using embryos obtained by in vitro fertilization (IVF). In this study, we conducted superovulation, IVF, and knock out and knock in using IVF rat embryos. We found that superovulation effectively occurred in the synchronized oest ...[more]